In Pathogenic, you are the disease.
Experience a visceral 2D roguelike twin-stick shooter where you play as a lone parasite fighting a desperate war against the immune system. Your goal is simple: infect and completely conquer your human host.
To survive, you must adapt. Hunt down enemy cells, rip out their organelles, and graft them onto your own body. Evolve from a simple cell into a complex engine of destruction, creating powerful, game-breaking builds to become the ultimate pathogen.
CREATE YOUR OWN PATHOGEN
Loot, graft, and assemble your parasite from dozens of unique organelles. Combine lashes for movement, mitochondria for power, secretors for ranged attacks, and spikes for melee combat. Discover powerful synergies to build an unstoppable disease.
FIGHT THE IMMUNE SYSTEM
Battle a diverse roster of enemies, from basic immune cells like macrophages and T-cells to rival parasites such as tapeworms or protozoa. Formidable bosses are lurking deep within the host's organs.
EXPLORE A MICROSCOPIC WORLD
Navigate the human body, a procedurally generated world of organic wonder. Travel through distinct biomes like the branching pathways of the lungs, the pulsating chambers of the heart, and the complex neural network of the brain.
FEEL THE ORGANIC ACTION
Our detailed, colorful world is powered by a soft-body physics simulation, giving every cell, enemy, and projectile a uniquely satisfying organic feel. The combination of hand-crafted design and procedural generation ensures that no two runs are ever the same, offering endless, challenging gameplay that always stays fresh.
Happy New Year everyone!
2026 is here! And we hope you have an amazing start to the year! Usually this wouldve been a patch notes post, though the next batch of new content needs a little more time to cook. Still, we want to keep you updated on the development progress so instead, we have a dev blog for you today on what weve been working on lately.
Tool Tips Rework
Pathogenic has seen a significant growth in wishlists ever since the demo launch, and we are incredibly grateful for that. With new parasites joining the battle every day, we want to make sure everyone can quickly grasp the fundamentals to invade and survive a hostile immune system. Thats why Matt and Roberto are overhauling the tool tips, which is a sizeable task across all localizations and we would like to take the time to get it right. Ultimately, you can expect more insightful and concise guidance as you begin your microscopic conquest.
Concept Art Showcase
At the same time, Matt and Roberto have been exploring new ideas for Pathogenic. Heres a collection of concept art on work-in-progress content:
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/d5aa7c9a172be562877a16a00dcf8f6b0c8da933.jpg\"][/img]After the recent changes, we believe the UI still has room for improvements. Here are some possible combinations of a new UI. Which one do you prefer?
[img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/0fba127cb7bc312bcb6720fbdb1b6678785b12e2.jpg\"][/img]
A much requested feature is to customize Pathogens before starting a run, and you can see some ideas of how it can be incorporated on the left. We are also thinking of introducing challenges to your runs, which players can complete with their ever-growing collection of organelles. This should provide players with a fun and rewarding incentive for more variations of playstyles.
[carousel][img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/83bad12a861664cdcc80ff82c748250900597de7.jpg\"][/img][img src=\"https://cdn.cloudflare.steamstatic.com/steamcommunity/public/images/clans/45656802/f8c0fe91d417ab07ef5078a868a7a8f99de6628d.jpg\"][/img][/carousel]In the previous patch notes weve shared a screenshot of the WIP intestine, and we have some unique flora and fauna in mind for this new area. New enemies will lurk around every corner to shut down your advance, and your pathogen wont be the only one with new tricks here!
On that note, let\'s conclude this quick dev blog. We hope you are looking forward to the new content that will be coming to Pathogenic, and Matt and Roberto have plenty of things planned. 2026 is going to be a big year so keep your eyes peeled for more news from us! We wish everyone an amazing start to the new year, and well see you again when the next update arrives.
Minimum Setup
- Graphics: GTX 1050
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